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 Cleanroom grade standards  The grades of cleanrooms are usually divided according to the number and size of particles allowed in the air. Internationally, ISO 14644 is usually used for grade classification. According to this standard, the grades of cleanrooms are from high to low: ISO 1-9. It should be noted that cleanroom standards can vary depending on the specific industry and application. In semiconductor chip production, cleanroom standards are usually more stringent to ensure that the quality and performance of the chips produced meet expectations. Cleanroom levels can be divided into: Class 1 > Class 10 > Class 100 > Class 1000 > Class 10000 > Class 100000 > Class 300000. Class 1 cleanrooms are mainly used in the microelectronics industry for manufacturing integrated circuits, and the precision requirements for integrated circuits are submicron. Class 10 cleanrooms are mainly used in the semiconductor industry with a bandwidth of less than 2 microns. Class 100 cleanliness is widely applicable and can meet the cleanliness needs of most industries. It can be used for aseptic manufacturing technology in the pharmaceutical industry. This cleanroom can be used for surgery for the manufacture of transplants and integrators, as well as isolation treatment of patients who are particularly sensitive to bacterial infections. Class 1000 cleanrooms are mainly used for the production of fine optical products, and are also used for testing, assembly of aircraft gyroscopes, assembly of fine micro bearings, etc. Class 10000 cleanrooms can be used for the assembly of hydraulic equipment or pneumatic equipment, and in some cases are also used in the food and beverage industry. In addition, Class 10000 cleanrooms are also widely used in the medical industry. The permissible particle concentration of 0.5um in a Class 1000 clean room is less than 35200 (pc/m3), and the permissible particle concentration of 5um is less than 293 (pc/m3). 2. The permissible particle concentration of 0.5um in a Class 10,000 clean room is less than 352000 (pc/m3), and the permissible particle concentration of 5um is less than 2930 (pc/m3).      Safety considerations  The decoration of semiconductor cleanrooms must meet safety requirements. Generally speaking, there are a large number of flammable and explosive substances in semiconductor cleanrooms, so the relevant national safety regulations, such as fire prevention and explosion prevention, should be followed during decoration. In addition, environmental pollution and the health and safety of staff should also be considered to ensure that the decoration materials meet national standards and will not cause harm to human health.    Cleanroom air treatment system  Semiconductor cleanrooms require air treatment systems to ensure the cleanliness of the air in the workshop. The air treatment system is mainly composed of air filters, air supply systems, return air systems and exhaust systems. Among them, air filters are an important component that can effectively remove particulate matter and microorganisms in the air.    Floor, wall and ceiling decoration    In the decoration of semiconductor cleanrooms, the decoration of floors, walls and ceilings is very important because these areas are susceptible to pollution. The floor should be made of wear-resistant, anti-static and easy-to-clean materials, such as Epoxy self-leveling floor or PVC plastic floor; the walls and ceilings should be made of corrosion-resistant, anti-static and easy-to-clean materials, such as aluminum plates, stainless steel plates, glass curtain walls, etc.    Layout of electrical equipment such as lamps and sockets    In the decoration of semiconductor cleanrooms, the layout of lamps and sockets is also very important. In order to prevent pollutants such as dust and microorganisms from entering the workshop, these devices should be installed on the ceiling or above the wall height, and anti-static and non-powder-shedding materials should be selected.    Doors, windows, clean workbenches and other facilities    In the decoration of semiconductor cleanrooms, doors, windows, clean workbenches and other facilities also need special consideration. Doors and windows must be made of materials with good sealing performance and easy to clean, such as stainless steel doors and windows; clean workbenches should be made of materials that do not shed powder, slag particles, are corrosion-resistant and easy to clean, such as stainless steel workbenches.

From May 28th to 30th, the three-day SEMICON Southeast Asia 2024 was held in the Malaysia International Trade and Exhibition Center (MITEC)! KLC has been deeply involved in the clean industry for more than ten years. It appeared at SEMICON Southeast Asia 2024 to explore new trends and opportunities in the semiconductor industry with colleagues from the global industry.    2024 SEMICON Malaysia International Semiconductor Exhibition  SEMICON Southeast Asia is the largest semiconductor equipment exhibition in Southeast Asia. Attendees are offered the opportunity to discover new technology trends and markets, with a focus on key technologies and regional markets, where exhibitors can collaborate with new suppliers and discover new solutions. The purpose of this exhibition is to promote semiconductor technology through technology, innovation, and design.   At this event, KLC displayed brand-new filters, transfer windows and other equipment products. Visitors stopped at the booth to learn more about KLC clean systems. At the same time, KLC had in-depth exchanges with industry experts and companies from all over the world, and jointly discussed the needs and trends of clean rooms in the semiconductor industry, helping us to continuously improve and innovate products and services.     This exhibition was a very meaningful and valuable experience. We thank all participants and organizers for giving us the opportunity to demonstrate our expertise and technical strength. We hope to work with you in the future to jointly promote the development and progress of semiconductor clean production space and create a better production environment!

From May 21st to 23rd, the 3-day 2024 Nigeria Lagos HVAC Exhibition (MEGA CLIMA) came to a perfect end! During the period, the KLC booth attracted the attention of many exhibitors and visitors. The team members enthusiastically introduced the characteristics and advantages of filters and equipment to visitors, and won the recognition and favor of many potential customers.   Let's review the wonderful moments of 2024 MEGA CLIMA together!   During the 3-day exhibition, KLC fully displayed the clean room solutions and new refrigeration and HVAC filter products of the refrigeration and HVAC industry, and had in-depth exchanges with professionals in West Africa and surrounding areas, opening up a broader clean industry space and market.     Through this exhibition, the confidence guarantee of KLC products was brought to the Nigerian HVAC and refrigeration market, and new possibilities were brought for the application of HVAC and refrigeration products in the new era and various industries. Every separation is for a better meeting next time. Thank you for your trust and recognition of KLC, and thank you for your expectations of new friends! I hope to work with you in the future to contribute to clean production space and low-carbon life!

We will exhibit at MEGA CLIMA NIGERIA 2024 from May 21st to 24th.   We believe that your participation will add more value to the exhibition. We sincerely invite you to participate in the exhibition and discuss the development trends and future opportunities of clean rooms in the refrigeration field. If you need more information or have any questions, please feel free to contact us.    BOOTH： MEGA CLIMA #B07  Address:  Landmark Centre, Lagos-NIGERIA  Time:  May 21-23, 2024   Thanks! Sincerely  

Dear customer,   On this special occasion, I would like to express my sincerest blessings to you. As New Year’s Day approaches, I wish you and your family happiness, health, and success in the new year. Thank you for your trust and support in us over the past year. Your trust is the driving force for us to keep moving forward, and your support is the source of our continuous growth. We will continue to work hard to provide better services in return for your love. Wish you a Healthy，Wealthy and Lucky 2024！  

On April 19, the CPHI Japan 2024 came to a successful conclusion in Tokyo. CPHI JAPAN 2024 hold at Tokyo Big Sight, from April 17th to 19th. KLC showed up with clean room solutions and discussed new development trends and future opportunities in the pharmaceutical industry with experts and audiences.     During the exhibition, KLC displayed a complete set of pharmaceutical clean room equipment and filter products, attracting the attention of many attendees. Participants had an in-depth understanding of product features and application scenarios through communication with KLC representatives.   Going global in 2024 has allowed KLC to increase its visibility and influence in the pharmaceutical industry. KLC promises to continue to be committed to the innovation and development of indoor air solutions, provide customers with better services, and make greater contributions to environmental protection. Looking forward to our next encounter!

The 2024 Russian Electronic Components and Production Equipment Exhibition (ExpoElectronica/Electrontech 2024) hold at the Crocus-Expo IEC Exhibition Center in Moscow from April 16th to 18th! KLC debuted with clean room solutions for electronics factories.     Expo Electronica, the International Electronics and Production Equipment Exhibition in Moscow, Russia, is an authoritative electronic basic product exhibition in Russia. It covers the entire electronic product industry chain from chips to finished products. It is a representative professional electronics exhibition in Russia and Eastern Europe. It is a UFI certified exhibition. Supported by the Russian government and professional electronics associations. It is understood that the electronics industry is one of the important components of Russia's modern industry. It is expected that by 2025, the Russian electronic systems market will increase to more than 42.6 billion euros.    KLC exhibition scene grand scene    KLC Cleantech located in Guangzhou China, is a professional and experienced manufacturer for air purification equipment for 19 years, owning ISO9001, ISO14001, CE, RoHS, UL, our aim is to provide high quality products and healthy air to customers with ultimate comfort.   At ExpoElectronica 2024, KLC showed up with innovative DOP Laminar Flow Hoods, Pass Box, Weighing Room and FFU products, which not only attracted the attention of exhibitors, but also attracted consultation and exchanges from many exhibitors at home and abroad.     Over the past 19 years, KLC has remained true to its original aspirations and strived to provide sustainable air purification solutions to global industrial manufacturing companies. In the future, KLC will continue to forge ahead! See you at the next stop!

Recognizing the paramount importance of a superior HEPA filter and its manufacturer is crucial for maintaining a safe and healthy environment in your home or office.   A HEPA filter is a specialized device designed to eliminate up to 99% of airborne particles that pass through it. This characteristic makes them indispensable components in HVAC systems and air purifiers.   For those seeking guidance on selecting the optimal HEPA filter manufacturer, read on!   Understanding HEPA Filters: Selecting the Right One   HEPA stands for High-Efficiency Particulate Air, representing a category of air filters extensively used in HVAC systems, air purifiers, and various other applications. Engineered to eradicate 99.97% of particles sized 0.3 microns or larger from the air that traverses through them.   When considering a HEPA filter for your home or business, it's imperative to factor in the required airflow for the designated room. In the case of using an air conditioner, ensuring ample airflow from your central A/C unit to circulate the entire area covered by the filter is essential.   Moreover, if you share your living space with pets or smokers, the selection of a filter capable of effectively removing pet dander and cigarette smoke from the surrounding air is of paramount importance. Keep in mind that certain filters excel in this aspect more than others, making it imperative to acquaint yourself with this information before making a purchase.   A HEPA filter, short for High-Efficiency Particulate Air filter, is a highly effective type of air filter made of fibrous materials. It sets the standard for air filtering efficiency and is recommended for minimizing common household allergens like dust, dander, and more.   Unlike standard air filters, HEPA filters are mechanically pleated to create a dense mat of randomly arranged fibers. This unique structure allows them to effectively capture particles of various sizes. When air particles pass through the filter, they are captured through three different mechanisms: interception, diffusion, and impaction.   Diffusion: This occurs when gas molecules smaller than 0.1 microns collide with each other, causing a delay as they pass through the HEPA filter. This delay increases the likelihood of the subsequent two processes taking place for smaller particles.   Interception: This process takes place when a dust particle is carried by the air but stays close to the fiber as it moves through. It depends on the size of the fiber and is most effective when the fiber's diameter closely matches that of the particle. The majority of medium-sized particles are captured through interception.   Impaction: Larger particles cannot avoid contact with the fibers as they move through the air, causing them to be embedded directly into the fibers.   Additionally, if particles carry a positive or negative charge and come in close proximity to fibers with an opposite charge, an electrostatic attraction is created, further enhancing the filtration process. This additional mechanism ensures that charged particles are effectively captured.

The 2023 egypt International Pharmaceutical Exhibition (2023Pharmaconex egypt) was held in Cairo, Egypt from September 3-5.       KLC，as a high-tech enterprise integrating the research and development, production and sales of products in the field of air purification, we continue to cultivate deeply in the field of air purification. The first stop of the 2023 overseas exhibition, KLC brought a new air filtration system to the Egyptian Pharmaceutical Exhibition, with a good reputation and high-quality products, which has been recognized by customers from different countries.   Pharmaconex Egypt is the leading professional trade exhibition for pharmaceutical raw materials, pharmaceutical machinery, and laboratory equipment in North Africa. During the exhibition, multiple forums and seminars hold, covering the quality monitoring and testing of the pharmaceutical industry, pollution discharge treatment technology, purification processes, supply chain management, North African pharmaceutical market overview, etc., providing enterprises with opportunities to access cutting-edge technology and industry direction.   2023 KLC Overseas Exhibition First Stop come to a successful conclusion！   The exhibition site is brilliant   During the exhibition, KLC brought many innovative and competitive products such as air purification solutions and air filters for the pharmaceutical industry. During the exhibition, KLC attracted distributors and experts from the global pharmaceutical industry to visit the booth to talk about friendship and look for new opportunities for cooperation, and KLC greeted them with full enthusiasm, and the two sides exchanged in-depth industry dynamics, trends, and wisdom mingling.   2023 KLC Overseas Exhibition First Stop come to a successful conclusion！We would like to express our sincere thanks to all our friends for their presence, support and affirmation to KLC! On the international stage, KLC always "make products with wisdom, do service with heart", and strive to bring more efficient products to every part of the world! Looking forward to the next encounter!

    With the continuous development of science and technology, the air quality of our life is getting worse and worse, making modern industrial production and scientific experiment activities of indoor air cleanliness is getting higher and higher. In particular, the medical industry requires miniaturization, refinement, high purity, high quality and high reliability of the indoor environment, which has high requirements for the performance of air filters.     At present, the main way to achieve this requirement is to widely use air filters in clean air conditioning systems.     The performance of various types of air filters is directly related to the grade of clean operating room. So, what are the types of air filters? What about its performance and adaptability?  Classification of air filters in clean operating rooms      Removing dust from the air relies on air filters. Filter is the core equipment in the process of air purification. The purification system is usually equipped with three stage air filtration. The first stage is at the fresh and return air outlets, the second stage is at the positive pressure section of the system, and the third stage is at the supply air end.     There are many kinds of filter, according to our national standard GB50073-2013 "clean factory design specification", the air filter is divided into four categories according to the following indicators:   Categories Filter object Initial resistance Primary air filter Particle size ≥5μm <30(Pa) Medium effect air filter Particle size 1um~5um <90(Pa) HEPA filter Particle size 0.3μm <150(Pa) ULPA filter Particle size 0.12um <220(Pa)    First, the primary air filter      Primary filter is the first level filter in air conditioning and purification system. It can also be used alone, as an air intake filter for ordinary air conditioning systems. All ventilation, air conditioning and purification systems with medium and high efficiency filters should be installed with primary filters.       The primary filter is mainly used to filter dust with particle size of more than 5um and various foreign bodies. It is suitable for the primary filtration treatment of simple air conditioning purification system and ventilation system and the occasions with high dust concentration.       Paper frame pleated filter, filter media is made of non-woven cotton and synthetic fiber by special blend, has the advantages of high dust capacity, low initial pressure loss, large air volume. The composite metal mesh provides the largest filter area for the air flow, and its filter area is 5 times that of the general plane filter. Humidity resistance up to 99%; Temperature resistance 80℃.     Mainly filter dust particles ≥5μm, used in commercial and industrial ventilation system, air conditioning system pre- filtration.  Second, medium effect air filter      In the air conditioning system, the medium effect filter is commonly used in the back of the primary effect air filter to improve purification efficiency, and in front of the high efficiency filter to extend the service life of the high efficiency filter.     The filter object of medium-effect filter is 1μm~5μm dust. The filter materials of medium effect filter mainly include polyester non-woven fabric, polypropylene non-woven fabric, medium cell foam plastic, fine cell foam plastic and medium effect glass fiber filter paper. The outer frame adopts special aluminum profile and galvanized steel frame.       Medium effect filter has the characteristics of strong tension, small resistance, large air volume and large filter area. It is suitable for intermediate filtration of air conditioning and air conditioning purification and occasions with high dust concentration. Medium filter is the most used bag structure, cleaning or replacement cycle is long.       Bag medium effect filter is suitable for intermediate filtration of air conditioning system, located in front of high efficiency filter, mainly used to filter 1-5μm dust particles, in order to protect the system filter and the system itself. It has the advantages of small resistance and large air volume. The optional styles are bag deep, frame type, combined type, etc.    Product features:  1. The filter material is made of high performance non-woven fabric with heat melting process, to avoid the discomfort of old glass fiber materials may cause to the human body; 2. The filter material contains electrostatic fiber, which has a particularly good filtering effect on sub-micron dust, with high dust capture rate, high air permeability, high dust load and high service life; 3. Filter material density increased step by step to increase the amount of dust, improve the service life of the product 4. Low initial resistance, high efficiency; 5. The appearance color uses uniform identification, easy to identify.    Third, HEPA filter      High efficiency air filter is the last stage filter in the purification system. The filter object is mainly 0.3μm~1μm dust.       For particles greater than or equal to 0.3um, the filtration efficiency is greater than or equal to 99.9%. Specifically can be divided into: V-bank filter, separator filter, mini-pleated filter.     V-bank filter, using acrylic filter paper and glass fiber filter paper as filter material, hot melt glue and silk wire as separator, outer frame plastic and plastic frame glued together. It has a large filtration area, low resistance, rated air volume and other characteristics, the general filtration efficiency of 99.97%~99.99%.       Mini-pleat HEPA filter, using thin glass fiber as filter material, hot melt adhesive as separator, metal protective mesh and filter material frame configuration, with high filtration efficiency. HEPA filter efficiency is 99.995% (0.3μm particles), ULPA filter efficiency is 99.9995% (0.1μm~0.2μm particles). Suitable for Class100-Class1000 class clean room and clean room terminal filtration device with high cleanliness rate requirement.    Fourth, electrostatic air filter      Electrostatic air filter can effectively collect dust of different particle sizes suspended in the air. In particular, 0.1μm~0.01μm particles that are difficult to be removed by ordinary air filtration can be removed by electrostatic filters.       Electrostatic filters also have the function of sterilization. Experiments show that the bacterial cysts are negatively charged. When entering the electrostatic filter's high voltage electric field, they are first polarized and positively charged. Then they enter the dust collection area and are absorbed by the high voltage electric field, and the bacterial cysts are neutralized and decomposed, thus achieving the effect of sterilization.       In order to ensure the good effect of surgical cleanliness, professional businesses should be consulted in the design of clean operating rooms. Understanding the performance of various air filters, reasonable optimization combination, in order to ensure the purification efficiency under the premise of achieving a reasonable cost performance.       And before installation, all kinds of filters are scanned for leak detection. After installation, leakage detection is carried out on the connection and compaction sealing parts to ensure the absolute reliability of the seal. Check the primary, medium and high filters regularly during use to ensure the normal operation of the filter system.

As an industrial air filtration equipment manufacturer, we understand the importance of maintaining clean and controlled environments in various industries. One key component in achieving this is the selection of the right cleanroom clean bench. In this blog post, we will explore the considerations for choosing vertical flow cleanroom clean bench and horizontal flow cleanroom clean bench, based on different industry requirements. Vertical Flow Cleanroom Clean bench: Vertical flow cleanroom clean bench provide a downward airflow that ensures particle containment and minimizes cross-contamination. They are often preferred in industries such as pharmaceuticals, biotechnology, and electronics manufacturing. Here are the key points to consider: Particle Control: Vertical flow clean bench excel in particle control, especially in environments where avoiding contamination is critical. Sterile Processing: Industries such as pharmaceuticals and biotechnology require a high degree of sterility to ensure product safety and quality. Protection of Sensitive Samples: Vertical flow clean bench provide a controlled environment for handling delicate samples and materials. Horizontal Flow Cleanroom Clean bench: Horizontal flow cleanroom clean bench introduce a laminar airflow parallel to the work surface. They are commonly used in industries like research laboratories, medical device manufacturing, and precision engineering. Here's why you should consider them: Operator Comfort: Horizontal flow clean bench provide better ergonomic conditions for operators, as the airflow is not directed towards their faces. Airborne Contaminant Control: In certain industries, such as fine optics or certain research applications, controlling airborne contaminants is crucial. Flexibility and Space Optimization: Horizontal flow clean bench allow for easier movement of equipment and samples on the work surface while maximizing space utilization. Conclusion: Choosing the right cleanroom clean bench is crucial for maintaining controlled environments in various industries. Vertical flow clean bench excel in particle control and sterile processing, while horizontal flow clean bench offer operator comfort and flexibility. The decision should be based on the specific industry requirements, such as the need for particle control, sterility, or operator comfort. Consult with experts in the field and evaluate your industry's unique needs to make an informed decision.   Remember, regardless of the type of cleanroom clean bench chosen, regular maintenance, proper airflow monitoring, and adherence to industry standards are essential to ensure the desired level of cleanliness and contamination control.   For further information or assistance in selecting the right cleanroom workbench solution for your industry, please don't hesitate to contact us.

Disinfection and sterilization are two different concepts. The disinfection and sterilization methods commonly used in biological clean room are compared, and three common methods such as ultraviolet sterilization, formaldehyde disinfection and ozone disinfection are described.    Part 1 Foreword  According to data, the human body about every 6~7cm2 of skin can carry 1~10000 bacteria, of which about 1% is pathogenic, human breathing, speech will also emit bacteria. Obviously, for clean workshops, especially biological clean rooms with relatively high cleanliness requirements, it is crucial to prevent the generation, removal and elimination of bacteria. Disinfection and sterilization are two effective methods to remove and destroy bacteria and ensure the microbial requirements of biological clean rooms.      Part 2 Disinfection and sterilization are two different concepts  Disinfection and sterilization are two different concepts. Sterilization, which is to kill or remove all microorganisms (including bacteria, viruses, etc.) in a substance, has absolute significance. That is to say, corresponding to sterilization is not sterilization, there is no intermediate state of more and less sterilization. In this respect, absolute sterilization is almost non-existent because it is difficult to achieve or for an infinite period of time. Disinfection is a treatment that kills most pathogenic microorganisms or reduces them to a certain extent. In this process, some bacteria or viruses are not destroyed due to resistance to heat or drug force, which has a relative significance. In other words, the disinfectant itself has a certain range of sterilization.   It is not difficult to see that the understanding of the relative and absolute meaning of disinfection and sterilization here is different from our usual understanding. What we usually call "sterilization" should be accurately called "sterilization".    Part 3  Comparison of common disinfection and sterilization methods  Disinfection and sterilization, from the mechanism point of view, there are no more than four: dry heat method, wet heat method, drug method, electromagnetic radiation method. From these four basic methods, a variety of disinfection and sterilization methods with different application scopes and application effects are derived.    3.1 Common sterilization methods  Commonly used sterilization methods are: high temperature dry sterilization, high pressure steam sterilization, gas sterilization, filtration sterilization, radiation sterilization and so on.    3.2 Common disinfection methods  Commonly used disinfection methods are: boiling and atmospheric steam disinfection, low temperature disinfection, ultraviolet irradiation disinfection, pharmaceutical disinfection and so on.    Part 4 Ultraviolet sterilization  Ultraviolet radiation is a kind of electromagnetic radiation method, which has many applications in local clean workshops, but its effect is limited, because the effect of ultraviolet light is limited, it can not be used to replace chemical disinfection, and ultimately sterilization, and ultraviolet radiation can not be used."    1、Factors influencing the effect of ultraviolet disinfection and sterilization   The factors that affect the effect of ultraviolet disinfection and sterilization are:  （1）Lamp use time: the bactericidal power of the ultraviolet lamp decreases with the increase of the use time, in general, the output power of the ultraviolet lamp after 100h is the rated output power, and the lighting time of the ultraviolet lamp to 70% of the rated power is the average life. The average life of domestic UV lamps is generally about 2000h. （2）Environmental conditions: Generally, under the conditions of ambient temperature of 20℃ and relative humidity of 40~60%, the sterilization effect of UV lamp is the best. When the temperature is 0℃, the sterilization effect is less than 60%. （3）Irradiation distance: within 500mm from the center of the lamp, the irradiation intensity is inversely proportional to the distance, and above 500mm, the irradiation intensity is approximately inversely proportional to the square of the distance. （4）Strain: Because of the membrane structure and shape of the bacteria, the bactericidal effect of ultraviolet light on the strain, that is, the bactericidal rate is also different. If the product of irradiation intensity and irradiation time is assumed to be the irradiation dose, when the required dose of E. coli is 1, staphylococcus, tuberculosis bacillus and the like need about 1~3, subtilis and its spores and yeast and the like need about 4~8, mold about 2 ~ 50. （5）Installation method: The penetration rate of ultraviolet light is low, which is greatly affected by shielding and installation method. In the biological clean room, there are generally several installation methods of chandeliers, side lights and overhead lights, of which the sterilization effect of overhead lights is the best. Due to the limitations of ultraviolet sterilization effect and the damage to the human body that may be caused by sterilization, the use of ultraviolet lamps for comprehensive sterilization of biological clean rooms has been rarely used, only individual rooms or local sections such as dressing rooms, laundry rooms, etc. At present, ultraviolet sterilization is commonly used in combination with HVAC system gas phase cycle disinfection.    2、Gaseous phase cycle disinfection  Gaseous phase cycle disinfection, is to take some measures, let the air organized circulation through the ultraviolet lamp effective irradiation area, increase the irradiation time and irradiation intensity at the same time, the ultraviolet radiation does not leak hurt, and does not produce ozone, so the ultraviolet lamp can not be turned off to achieve the purpose of circulating air disinfection, disinfection effect is also greatly improved.    Part 5 Formaldehyde disinfection  Formaldehyde disinfection is a kind of pharmaceutical disinfection, and is also a common way of biological clean room disinfection. There are two kinds of formaldehyde disinfection: first, on-site disinfection, only a small range of disinfection in the local space of the clean room, formaldehyde can be used directly in the room evaporation (or heating evaporation), the effect is poor, and the detoxification after disinfection is inconvenient. The other is combined with the HVAC system, formaldehyde from the disinfection tank with jacket overflow into the air supply point main pipe of the air conditioning unit and then into the clean room, in order to increase the evaporation intensity of formaldehyde, the disinfection tank jacket through the steam. It should be noted that because formaldehyde contains trace amounts of formic acid, it has a certain corrosive effect on galvanized air pipes, and it is recommended to use stainless steel pipes.    Part 6 Ozone disinfection  Ozone disinfection is a newly developed disinfection method. It is characterized by easy to use, safe, flexible installation and obvious bactericidal disinfection.   Ozone disinfection requires the installation of an ozone generator. The ozone generator can be installed in a variety of ways: desktop, mobile or split type, placed directly in the clean room that needs disinfection; Pipe type, can be installed in the HVAC system's supply and return air main pipe (where the air pipe needs to be expanded); In addition, the ozone generator can also be fixed on the back end of the efficiency filter in the purification air conditioning unit. The latter two installation methods not only disinfect the clean room internally, but also disinfect the air ducts, filters, and internal equipment of the HVAC system. At present, ozone generators used in clean room disinfection have been produced by a number of domestic manufacturers. The amount of ozone that needs to be consumed when ozone disinfection is used in a biological clean room (or the output of the ozone generator that needs to be selected is the discharge water) can be referred to the relevant manufacturer's information. Compared with formaldehyde disinfection, the advantage of ozone disinfection is that it is easy to install and non-corrosive to air ducts and filtration materials when combined with HVAC systems.    Part 7 Conclusion  （1）Disinfection and sterilization are two different concepts. （2）The choice of disinfection and sterilization method should be determined according to the decoration, equipment and material of the biological clean room, production characteristics, etc., and consider the corrosiveness and economy of the disinfectant, the convenience, safety and the feasibility of GMP verification. （3）Formaldehyde and ozone are two commonly used disinfection methods. The GMP Certification Guide recommends the use of ozone disinfection. （4）Either way, it should be used in conjunction with the HVAC system in the clean room. For the residue that is harmful to people after disinfection, it should be diluted to a safe concentration through the ventilation device in time. （5）Any disinfection methods, disinfectants have a certain degree of resistance, and should be replaced after a period of use.