The mobile self-cleaning device shells are made of cold-rolled steel sheets, baking varnishes, self-contained fans, mesh pre-filter, air supply static pressure boxes, HEPA filters and flow equalizer plates. Variable air volume fan system with multiple speeds. The air outlet end of the self-cleaning device can get a high cleanness local environment and can be used with related equipment. The bottom of the air self-cleaning unit is provided with a brake caster and an adjustable foot cup, which can be moved to the desired position and fixed after being required.